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Prabodhika Mallikaratchy

Assistant Professor

Analytical Chemistry, Lehman College
Antibody Guided Cell-SELEX Technology

Professor Mallikaratchy investigates how molecules react and her training as an aptamer chemist resulted in her first NIH National Institute of General Medical Sciences, $450K, four-year award for her research project, Antibody Guided Cell-SELEX Technology. Aptamers are single-stranded DNA molecules that bind to certain proteins with high affinity. They have significant value in biotechnology for the development of aptamer-based therapeutics. Mallikaratchy seeks to identify the molecules that bind to different targets in lymphoma and leukemia and uses an in vitro evolution process known as systematic evolution of ligands by exponential enrichment or SELEX technology. “We use existing molecule interactions to redirect the selection step in the SELEX process to identify highly specific aptamer molecules from a complex library.” Through this technological approach, she hopes to enrich the library of molecules that bind to specific epitopes expressed in B cell lymphoma and leukemia, learn how aptamer molecules evolve in the SELEX process, and expand the technology that can be applied in the clinical setting.

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