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Luis Cardoso

Professor

Biomedical Engineering, The City College
Mechanical Function of Trabecular Bone: Bone Loss Assessment Beyond BMD

During the onset of osteoporosis, there are many changes in the mass density, composition, and microarchitecture of bone that leads to a fragile structure and susceptibility to spontaneous fractures. Professor Cardoso seeks to understand the relationship between changes in microarchitecture in trabecular bone and how the changes in microarchitecture affect mechanical function in tissue through his four-year, $267K, NIH National Institute of Diabetes and Digestive and Kidney Diseases award, Mechanical Function of Trabecular Bone: Bone Loss Assessment Beyond BMD. Cardoso attempts to identify the key parameters in microarchitectural deterioration of the trabecular bone leading to a defective bone structure (such as vertebral collapse). “We are working to develop a non-invasive 3D ultrasound tomography approach that will detect those changes in microarchitecture and mechanical properties the current clinical approach cannot detect.” Cardoso hopes this new approach will improve the assessment and early detection of fracture risk.

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